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KMID : 1161420180210080793
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Journal of Medicinal Food
2018 Volume.21 No. 8 p.793 ~ p.800
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Antiobesity and Cholesterol-Lowering Effects of Dendropanax morbifera Water Extracts in Mouse 3T3-L1 Cells
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Song Ji-Hye
Kang Hee-Bum
Kim Ji-Hye
Kwak Sung-Min
Sung Gi-Jun
Park Seung-Ho
Jeong Ji-Hoon
Kim Hyun-Hee
Lee Jeong-Min
Jun Woo-Jin
Kim Yong-Jae
Choi Kyung-Chul
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Abstract
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Obesity is the most common metabolic disease in developed countries and has become a global epidemic in recent years. Obesity is associated with various metabolic abnormalities, including glucose intolerance, insulin resistance, type 2 diabetes, dyslipidemia, and hypertension. Leaves from the plant Dendropanax morbiferus are beneficial to health as they contain high levels of vitamin C and tannin. There have been seminal studies on the anticancer, antimicrobial, antidiabetes, and antihyperglycemic effects of treatments with D. morbiferus trees. Herein, we investigated the toxicity of D. morbiferus water (DLW) extracts in vitro, and demonstrated no toxicity at 5?500?μg/mL in 24?72-h experiments with 3T3-L1 cells. The DLW increased cell viability at 48?h and inhibited adipogenesis in 3T3-L1 cells by reducing intracellular triglyceride levels and glucose uptake. In addition, mRNA and protein expression levels of adipogenesis-related genes were lowered by DLW, suggesting antiobesity effects in mouse 3T3-L1 cells. Because few studies have demonstrated cholesterol-lowering effects of D. morbiferus, we investigated the activities of adipogenic transcriptional factors following treatments of 3T3-L1 cells with D. morbiferus and observed increased CEBPα, CEBPβ, PPARγ, and SREBP1 activities in the cells, indicating that DLW extracts inhibit adipogenesis.
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KEYWORD
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3T3-L1, antiobesity, cholesterol lowering, Dendropanax morbiferus, metabolic disease
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